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one embodiment, the method comprises introducing into the prokaryotic organism an expressible nucleic acid encoding a putatively essential gene for proliferation or pathogenicity under the control of a promoter and at least one tet operator, and an expression vector comprising a nucleotide sequence encoding a modified tetracycline repressor, wherein said modified tetracycline repressor binds to a tetracycline operator sequence in a prokaryotic organism with a greater affinity in the presence of tetracycline or a tetracycline analog than in the absence of tetracycline or a tetracycline analog.
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The term "heteroatom" includes atoms of any element other than carbon or hydrogen! Cyclic alkyl groups include groups with one or more rings, such as, for example, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, etc.
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